|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05.
|
31759989 |
2020 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the subgroup analysis, we identified a significant association between PGC-1<i>α</i> rs8192678</span> polymorphism and T2DM in the Caucasian and Indian populations under all genetic models we investigated.
|
30944665 |
2019 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to analyse the association between PPARG rs1801282, PPARGC1A rs8192678, VEGFA rs2010963, ADRA2A rs553668, KCNQ1 rs2237892, SIRT1 rs7896005, IGF2BP2 rs4402960, and UCP3 rs3781907 single nucleotide variants (SNVs) with T2D and metabolic traits in a case-control study of a population from Mexico City.
|
29800730 |
2018 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analyses conducted on rs8192678 and rs2970847 variants illustrated the overall effect of minor alleles providing a higher risk for the T2D development.
|
29063962 |
2018 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
All polymorphisms were in Hardy-Weinberg equilibrium, and the association by genotype with T2D-related traits displayed nominal significance for rs8192678 with glucose (<i>p</i> = 0.023) and triglycerides (<i>p</i> = 0.013); rs2010963 with diastolic blood pressure (DBP) (<i>p</i> = 0.012) and cholesterol (<i>p</i> = 0.013); rs7896005 with DBP (<i>p</i> = 0.012) and insulin (<i>p</i> = 0.011); and rs659366 with cholesterol (<i>p</i> = 0.034), glucose (<i>p</i> = 0.031) and triglycerides (<i>p</i> = 0.028); and the association of rs2010963 with HDL-C (<i>p</i> = 0.0007) was significant.
|
30393491 |
2018 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with T2D susceptibility, relative risk of obesity and insulin resistance, and lower indices of β cell function.
|
29186342 |
2018 |
|
rs2970847
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Meta-analyses conducted on rs8192678 and rs2970847 variants illustrated the overall effect of minor alleles providing a higher risk for the T2D development.
|
29063962 |
2018 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotype comparison analysis indicated that CTTCGGG and CTCTGGG haplotypes with the order of PPARG rs1801282 C>G, PPARG rs3856806 C>T, PPARGC1A rs8192678 C>T, PPARGC1A rs2970847 C>T, PPARGC1A rs3736265 G>A, PPARGC1B rs7732671 G>C and PPARGC1B rs17572019 G>A polymorphisms in gene position significantly increased the risk of T2DM.
|
28418876 |
2017 |
|
rs2970847
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Haplotype comparison analysis indicated that CTTCGGG and CTCTGGG haplotypes with the order of PPARG rs1801282 C>G, PPARG rs3856806 C>T, PPARGC1A rs8192678 C>T, PPARGC1A rs2970847 C>T, PPARGC1A rs3736265 G>A, PPARGC1B rs7732671 G>C and PPARGC1B rs17572019 G>A polymorphisms in gene position significantly increased the risk of T2DM.
|
28418876 |
2017 |
|
rs3736265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype comparison analysis indicated that CTTCGGG and CTCTGGG haplotypes with the order of PPARG rs1801282 C>G, PPARG rs3856806 C>T, PPARGC1A rs8192678 C>T, PPARGC1A rs2970847 C>T, PPARGC1A rs3</span>736265 G>A, PPARGC1B rs7732671 G>C and PPARGC1B rs17572019 G>A polymorphisms in gene position significantly increased the risk of T2DM.
|
28418876 |
2017 |
|
rs10212638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that Koreans with the minor alleles of PGC-1α rs10517030, rs10517032 and rs10212638 are at greater risk of T2DM, and that a low-energy diet is more protective against the development of T2DM in subjects with the major alleles of rs10517030 and rs10517032.
|
28488691 |
2017 |
|
rs10517030
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that Koreans with the minor alleles of PGC-1α rs10517030, rs10517032 and rs10212638 are at greater risk of T2DM, and that a low-energy diet is more protective against the development of T2DM in subjects with the major alleles of rs10517030 and rs10517032.
|
28488691 |
2017 |
|
rs10517032
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that Koreans with the minor alleles of PGC-1α rs10517030, rs10517032 and rs10212638 are at greater risk of T2DM, and that a low-energy diet is more protective against the development of T2DM in subjects with the major alleles of rs10517030 and rs10517032.
|
28488691 |
2017 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Using a range of Polynesian populations (Tongan, Māori, Samoan) we re-examined evidence for association between Gly482Ser with T2D and BMI as well as gout.
|
27846814 |
2016 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings revealed significant associations between PGC-1alpha Gly482Ser and Thr528Thr polymorphisms and type 2 diabetes in Kurdish-Iranians.
|
25282005 |
2015 |
|
rs4235308
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification with sex, in Haitian Americans, both rs4235308</span> (OR = 0.38, P = 0.026) and rs7656250 (OR = 0.23, P = 0.006) showed protective association with T2D in females whereas in African American males rs7656250 had statistically significant protective effect on T2D (OR = 0.37, P = 0.043).
|
25977930 |
2015 |
|
rs7656250
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification with sex, in Haitian Americans, both rs4235308 (OR = 0.38, P = 0.026) and rs7656250 (OR = 0.23, P = 0.006) showed protective association with T2D in females whereas in African American males rs7656250 had statistically significant protective effect on T2D (OR = 0.37, P = 0.043).
|
25977930 |
2015 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population.
|
22391941 |
2012 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus.
|
22684233 |
2012 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that Gly482Ser and Thr394Thr polymorphisms of PPARGC1A gene were significantly associated with the risk of T2DM, especially in the Indian population.
|
21294239 |
2011 |
|
rs3736265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No relationship was found between the Thr612Met and risk of T2DM.
|
21294239 |
2011 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this series, there was no association between G482S polymorphism and T2DM and obesity (body mass index >25 kg/m(2)).
|
19913841 |
2010 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data suggest that the PGC-1α Thr394Thr and Gly482Ser polymorphisms are associated with therapeutic efficacy of multiple-dose rosiglitazone in Chinese patients with type 2 diabetes mellitus.
|
20498286 |
2010 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Common polymorphisms of the peroxisome proliferator-activated receptor-gamma (Pro12Ala) and peroxisome proliferator-activated receptor-gamma coactivator-1 (Gly482Ser) and the response to pioglitazone in Chinese patients with type 2 diabetes mellitus.
|
20045142 |
2010 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Together, these results showed that PPARG Pro12Ala and PPARGC1A Gly482Ser variants are associated, alone and in interaction, with insulin and glucose homeostasis and suggest that gene-gene interactions should be taken into account in candidate gene studies of T2DM to identify subjects with markedly different risks of developing the disease.
|
19536736 |
2009 |